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Upregulation of LRP-1 solely in response to -synuclein pathology may be a compensatory clearing mechanism, further supported by the neuroprotective effects of inhibition of the LRP-1-cleaving Furin

[2] [4] In multi-compartment pharmacokinetics, two operational half-lives are often distinguished: an early distribution () half-life governed by redistribution from the central to peripheral compartments, and a later elimination () half-life governed by metabolic clearance and excretion

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds

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